NanoString Blog
Category: Oncology
nCounter Oncology
GEP Signatures Unleashed: The LST for Diffused Large B-Cell Lymphoma, DLBCL, Subtyping and Its Expanding Applications
Gene expression profiling (GEP) signatures, comprising sets of genes characteristic of specific diseases, tissues, cell types, cell states, or biological perturbation, hold significant diagnostic, predictive, and prognostic value, positioning them…
Immunology nCounter Oncology
TIS GEP: Use Cases in Sample Stratification, Assessment of Treatment Effect, and as a Component of a Multivariate Biomarker
Introduction to the TIS Gene Expression Profile Innovations in multiplex gene expression analysis are revolutionizing translational research and clinical practices by enabling identification of gene signatures involved in various biological…
Oncology
Utility of PAM50 GEP Signature as a Biomarker for Exploratory Endpoints in Drug Discovery and Development
The Need for Gene Expression Profiling Gene expression profiling has emerged as a genomic tool that can help decipher the complexity of cancer subtyping. Conceptually, cancer is a fairly simple…
Oncology
What is Comparative Oncology and Why Has it Gone to the Dogs?
Deciding which model system to use to answer biological questions is a critical choice in research. Many human diseases occur naturally or can be reproduced in animals. Depending on the…
Oncology
Five Key Milestones in the History of Research in Cancer Biology
On a cold snowy day in late November 2016, I sat with my father-in-law at the infusion clinic in the local hospital. I was visiting Pennsylvania for my mother-in-law’s funeral.…
Digital Spatial Profiling GeoMx DSP nCounter Oncology Spatial Transcriptomics
New approaches to CAR-T therapy
What is CAR-T cell therapy? In the fight against cancer, immunotherapies that enlist and strengthen the power of a patient’s immune system to attack tumor cells have revolutionized treatment paradigms.…
Immunology Infectious Disease Oncology
T-Cell Receptor Diversity…What Are You Missing?
The T cell receptor (TCR) is one of the distinguishing molecules of the adaptive immune system. TCRs allow mammalian immune systems to recognize and respond to foreign entities (pathogens, vaccines,…
GeoMx DSP Oncology
Breast Cancer: Best practices for using GeoMx® Digital Spatial Profiler
It’s October and breast cancer awareness month. Breast cancer kills more women than any other type of cancer. It isn’t just limited to women either - a man’s lifetime breast…
Oncology
What is the Next Frontier in Cellular Therapy?
In early June 2021, NanoString and the Parker Institute for Cancer Immunotherapy (PICI) announced a multi-center collaboration to characterize 800 CAR-T samples in a unique and concerted effort to understand…
Oncology
A “Tail” of Two Species: New Canine Immuno-Oncology Research Offering
NanoString has an unparalleled and longstanding tradition of developing best-in-class cancer research tools, thanks to an extensive knowledge accumulated in a decade of interrogating all aspects of the disease. Last…
Clinical Research Infectious Disease Oncology
Of Mice and Men: The importance of Mouse Models in Research
Many animals share common biology with humans, are affected by similar diseases, and may have a comparable response to certain treatments. Animal models are thus useful to address scientific questions…
Oncology
NanoString Proudly Introduces the new nCounter® Canine IO Panel.
It may have happened to you, as it happened to some of us here at NanoString®: the furry, four-legged trouble-making family member you just can’t stay mad at is sick,…