NanoString Blog
Category: Neuroscience
Neuroscience
Miranda Orr’s Spatial Analyses from Discovery to Validation Reveal Key Processes in Alzheimer’s Disease
Discover Dr. Miranda Orr’s cutting-edge spatial multiomics research in neuroscience, revealing new Alzheimer’s disease processes with advanced proteomic tools.
GeoMx DSP Neuroscience Spatial Biology
What is Chronic Traumatic Encephalopathy?
Chronic traumatic encephalopathy (CTE) is a progressive neurodegenerative disease affecting people who have suffered repeated concussions and traumatic brain injuries (TBI). CTE was first described in 1928 by Dr. Harrison…
Neuroscience Spatial Biology Spatial Transcriptomics
The Neuroinflammatory Puzzle of the Autoimmune Disease Multiple Sclerosis
What is Multiple Sclerosis? In 1868, a German physician Leopold Ordenstein and his mentor Jean-Martin Charcot, published a work that fundamentally changed our understanding of the disease Multiple Sclerosis1. For…
Digital Spatial Profiling nCounter Neuroscience Spatial Transcriptomics
Neurodegenerative disorders and Parkinson’s disease.
The idiom “to lose one’s nerves” is literally true when it comes to neurodegenerative disorders. These disorders are characterized by the progressive loss of disease-specific neural populations in the brain…
nCounter Neuroscience Spatial Transcriptomics
Alzheimer’s Disease Pathology: Fear, Confusion, and the Search for a Cure
Alzheimer's disease pathology: a short sentence loaded with fear, confusion, and incredulity. The word “Alzheimer’s” first appeared in a German psychiatry handbook called “General Psychiatry” on July 15, 1910. This…
Neuroscience
Meet the New Brainiacs in the Fight Against Neurological Diseases
The Liddelow Lab is part of the Neuroscience Institute at NYU Langone. The lab’s research focus is astrocytes and their involvement in human neurological diseases. The team discovered that different…
Autoimmunity Digital Spatial Profiling Neuroscience Oncology
Readers’ Favorite Webinars: A Year in Review
NanoString webinars allow you to sit back, relax and listen to a leader in the field talk about his/her research and/or answer your questions. They have always been a crowd-pleaser,…
Neuroscience
Of Inflammasome and Tauopathies in Mice and Men
Tauopathies are a class of neurodegenerative diseases characterized by the aggregation of tau proteins in neurofibrillary tangles in the human brain. These proteins are associated to microtubules and are found…
Neuroscience
A Strategic Attack Against Neurological Diseases
Neurological diseases are often multifactorial, brought on by a genetic and environmental tug-of-war and resulting in multifaceted clinical presentations. Such etiological complexity has hindered treatment progress and has necessitated well-thought-out…
Neuroscience
A Systematic Evaluation of Immune Response and Plaque Microenvironment Variation in Alzheimer’s Disease
Alzheimer’s disease (AD) – the most prevalent form of dementia – is associated with defining histopathological features that include amyloid-beta (Aβ) plaque deposition and tau protein aggregation, accompanied by synaptic…
Neuroscience
New Biology-Driven Drug Discoveries Needed for Treating of Alzheimer’s
Alzheimer’s disease (AD) is a slowly progressing neurodegenerative disorder that affects millions of people worldwide, leaving behind an immense psychological, emotional, and financial burden on patients, caregivers, and healthcare systems.…
Neuroscience
Q&A with Dr. Gregory Carter: Developing Computational Strategies and the MODEL-AD Consortium
Gregory Carter, Ph.D., is an Associate Professor at The Jackson Laboratory. His work is focused on developing computational strategies using genetic data to understand complex genetic systems. We recently spoke…